Funded Industry Led Projects


The IB Accelerator Programme (formerly known as the Exemplar Programme) is a series of funding competitions designed to support collaborative projects that address a defined market need or commercial opportunity through the innovative application of biotechnology.Through our competitive calls IBioIC have to date funded 27 Industry led projects with a total value of £6.9million and a total grant amount of £3.3million. Find out more about the projects we have funded below.

To find out about current funding opportunities please click here.

Award
Date

Project
Title

Total Project
Value

Industry Collaborator

Academic Collaborator


Jul-14
Optimising the production of  a biologically active microalgal polysaccharide.
Read case study
£237,169
IBioIC Funding
£135,308
GlycoMar Logo
University of Edinburgh Logo

Jul-14
Optimising the production of abiologically active microalgal polysaccharide
Read Case Study
£241,055
IBioIC Funding
£131,056
GSK Logo

Sep-14
Comparative transcriptomic and metabolomic analysis of engineered bacteria for the production of monomers using Industrial Biotechnology.
Read case study
£264,628
IBioIC Funding
£128,806
Ingenza Logo
University of Strathclyde Logo

Nov-14
Optimising biotechnological protein expression through predictive management of cellular translation
£281,814
IBioIC Funding
£112,870
Ingenza Logo
Aberdeen logo 

Nov-14
An in vivo route to anti-HIV cyclotides
Project Detail
This project proposes to develop a plug and play cyclotide production platform in bacteria by recruiting enzymes from cyanobactin pathways to support in vivo synthesis and enable further cyclotide improvements e.g. prenylation of the final product.
£318,513
IBioIC Funding
£142,189
Ingenza Logo
Aberdeen logo

May-15
Photodynamic enhancement of industrial feedstock production by microalgae through solar wavelength conversion
£113,396
IBioIC Funding
£72,184
Xanthella
St_Andrews

May-15
Development of novel enzymes for methacrylate biomanufacturing
£206,312
IBioIC Funding
£92,947
Ingenza LogoLucite
St_Andrews

May-15
Bioengineering with CRISPR-Cas to deliver non-GM yeast for industrial and agricultural applications
Project Detail
Genome editing to impact endogenous gene expression/activity is emerging as a powerful tool enabling the generation of designer microbes engineered for the optimal expression of high value industrial products. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and the CRISPR-associated (Cas) systems that occur naturally in bacteria use RNA-guided nuclease activity to provide adaptive immunity against invading foreign nucleic acids. Type II bacterial CRISPR-Cas system have been used in microbial production hosts for in situ genome engineering. In this project we aim to develop and deploy CRISPR-Cas9 based genome modification tools for industrial and agricultural application in yeast (S. cerevisiae).
£219,170
IBioIC Funding
£98,282
Ingenza Logo

May-15
Development of scalable purification
of functional oligosaccharides
Project Detail
The project will seek to develop state of the art platform processes for preparation of defined oligosaccharide products, using as examples two products under development by GlycoMar limited.
£218,134
IBioIC Funding
£139,606
GlycoMar Logo
University of Edinburgh LogoHeriot-Watt Logo

Oct-15
Design of inducible promoters for improved bioprocessing in mammalian cell systems
Project Detail
Production of biopharmaceuticals that are toxic or have detrimental effects on the growth of the host cell line is very challenging. Synpromics will apply its proprietary technology to develop new synthetic inducible promoters to improve productivity and minimize costs during bioproduction in CHO cells.
£105,909
IBioIC Funding
£29,703
Synpromics
University of Edinburgh Logo

Oct-15
New world by-products
Project Detail
Horizon Proteins extracts the protein from pot ale, a by-product from malt whisky production, for use as a local protein ingredient for salmon feed in Scotland. This project will look to adapt Horizon protein's technology to American Whiskey by-products and recover protein for use in local feed markets with the potential to replace grains which have been diverted from the table to the still.
£149,859
IBioIC Funding
£95,887
Horizon Proteins Logo
Heriot-Watt Logo

Feb-16
3f Diversity
Project Detail
This project will build on existing technology to produce bulk high protein food, and allow the detailed study and process development for the production of an animal feed supplement.
£149,859
IBioIC Funding
£95,887
3FBIO Logo
University of Strathclyde Logo

May-16
Real-time control of bioreactors with in-situ spectroscopy
Project Detail
Enhanced biological phosphorus removal (EBPR) will be used as a test case for the development of in-situ monitoring and optimisation of wastewater treatment bioreactors. Monitoring will be provided by Art Photonics' proprietary probe technology that can measure the Raman scattering and spectral absorption within bioreactors.
£155,680
IBioIC Funding
£99,635
Art Photonics Logo
University of Edinburgh Logo

Oct-16
RTMet: Real Time Metabolomics for Synthetic Biology Applications
Project Detail
This project aims to kickstart a revolution in synthetic biology-driven bioprocesses. Routine measurements, such as pH and oxygen content, are incapable of monitoring the accumulation of intracellular and/or extracellular products by themselves. Our goal is to enable real time monitoring of fermentation bioprocesses in a two phase project using mass spectrometry. 1: Adaptation of a method for extracellular real time profiling of succinate fermentation bioprocesses, allowing improved strain engineering of the microorganism. 2: Adaptation of the previous method for intracellular chemical profiling to improve understanding of the bioprocess. Identification of metabolic pathways could offer synthetic biology solutions to a bioprocess.
£485,838
IBioIC Funding
£199,102
Ingenza Logo
University of Glasgow Logo

Oct-16
Accelerating biotech production of saponins
Project Details
Unilever would like to use saponins in their home and personal care products. However, saponin extracts from plants are too expensive and variable in composition. Hence, we are developing a yeast platform for saponin production. Unfortunately, saponins are toxic to yeast. This project will explore four strategies to mitigate saponin toxicity and enable saponin yield to be commercially viable. These strategies include: • Tight control the final glycosyl transferase enzymatic step leading to the toxic saponin production. • Determine whether yeast cell membrane composition impacts on resistance to saponins. • Directed evolution for identification of a yeast chassis with enhanced saponin tolerance • Determination of structural features of saponins that confer toxicity to yeast.
£453,5485
IBioIC Funding
£200,394
Unilever Logo
University of Edinburgh Logo

Oct-16
Maximising the metabolic efficiency of cellular methacrylate production
Project Detail
The global market for methacrylate production is $6Bn and growing. Current industrial routes to methacrylates utilise harsh synthetic chemistry and there is demand for a greener more cost efficient route. Using synthetic biology we will develop a bacterium that maximises carbon conversion from glucose to alkylmethacrylate. Current approaches under development suffer from redox imbalance and require delivery of oxygen to the fermentation. In this project we seek to deploy several concerted pathways to prepare alkylmethacrylate from glucose and minimise the oxygen requirement. The project will deliver enhanced carbon conversion efficiency from glucose to product; thus, lessening waste CO2(g).
£426,832
IBioIC Funding
£194,063
Lucite Logo
St_Andrews

Oct-16
Engineering microbial cell factories for industrial carotenoids biosynthesis
Project Detail
This project aims to develop hyper-productive bacterial strains for industrial biosynthesis of high value carotenoids. We will synergistically exploit advances in synthetic biology and emerging single-cell technology to generate cell factories through an efficient “creation-and-selection” process. Creation will be through the engineering of hyper-productive Escherichia coli strains and the use of light induced stimulations to produce novel carotenoids within cyanobacteria. Selection is based on quantification of the carotenoid content of individual cells through snapshot spectroscopy. This process will address the two key challenges for industrial production of microbial carotenoids: 1) high yield cell factories and 2) new high value products.
£410,026
IBioIC Funding
£199,219
Nissan Logo 
University of Glasgow Logo

Oct-16
Engineering Tissue-Specific Synthetic Promoters (TSSP) Utilising a Novel High Content Enhancerome In Vivo Screen
Project Details
The project focuses on the creation of small, strong and tissue-specific synthetic promoters suitable for a variety of gene-therapy applications. It combines the functional analysis of the human ‘promoter-ome’ with Synpromics (SYNP) proprietary bioinformatics and library screening technologies to identify specific regulatory regions using an in-vivo screening model. There is a growing demand for tissue-specific promoters to prevent off-target effects in therapeutic applications. This project seeks to address these issues through the utilisation of a suitable AAV vector system and in vivo screen, thus providing an extensive functional data and promoter resource with high value for the gene therapy sector.
£682,173
IBioIC Funding
£196,479
Synpromics
University of Edinburgh Logo

Oct-16
Accelerating industrial metabolic engineering using YeastFAB
Project Details
The Cai laboratory, University of Edinburgh, has developed a robust automatable system, 'YeastFab' for rapid assembly of genetic constructs in Saccharomyces cerevisiae. This greatly facilitates the generation of new yeast strains for production of pharmaceuticals, flavours and fragrances, biofuels, and other valuable products from renewable resources. In this project, the University and Twist Biosciences will collaborate to generate a large library of promoters and other genetic components in YeastFab format and characterize them thoroughly under industrially relevant conditions. This library of validated components in an easy-to-assemble format will be a valuable resource, which will be commercialized by Twist.
£498,866
IBioIC Funding
£199,892
Twist Logo
University of Edinburgh Logo




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